Zinc modulates and controls the cellular microenvironment known as the Extracellular Matrix (ECM), thus regulating cell fate and the possibilities of growth or inhibition of cell growth.

It is a very important trace mineral that people need to stay healthy.

It is well known that it is essential in cell metabolism, important in protein synthesis and in the composition of metabolic enzymes.

It has been widely demonstrated that Zinc has important antioxidant activity, especially as a cofactor for the enzyme zinc-dependent superoxide dismutase (ZnSOD), responsible for neutralizing free radicals produced in excess in an organism. This means that it has an important action as an antioxidant.

It is also a fundamental element as a regulator of the immune response since it is known to play a key role in the normal activity of neutrophils and "natural killer" (NK) cells. It also influences the functions of T lymphocytes and B lymphocytes.

Functions:

Zinc is found in cells throughout the body. It is necessary for the immune system to function properly. It participates in cell division and growth, as well as in wound healing and carbohydrate metabolism.

Zinc is also necessary for the senses of smell and taste. During pregnancy, lactation, and childhood, the body needs zinc for proper growth and development. Zinc also increases the effect of insulin.

In addition to having effects on the immune system, it acts on DNA repair and is an essential part of free radical scavenging enzymes.

Several international protocols indicate it as effective in hospitalized patients with flu complications.

Selenium is essential as an antioxidant, immunomodulator and regulator of the ECM. It is an essential trace element that the body has to get to make special proteins, called antioxidant enzymes.

These participate in the prevention of cell damage.

It is a crucial element in the constitution of selenoproteins, which are essential enzymes to counteract oxidative stress. In this way, it has an important action as an antioxidant, contributing to the protection of DNA against oxidative damage. In addition, through selenoproteins and non-structural matricellular proteins, it regulates the functioning of DNA, in this way it is important in diseases such as cancer, both in its initiation and in the detection of the process.

There is evidence of its use in supplementation, particularly in respiratory diseases. Scientific works support its use in acute respiratory infections, predominantly in pneumonia. Zn and Se deficiency is common in children in developing countries due to the high incidence of malnutrition. The administration of Zn and Se shows the decrease in the incidence of these respiratory infections.

Additionally, Selenium may help prevent certain cancers, as mentioned above, and protect the body from the toxic effects of heavy metals and other harmful substances.

Manganese is an essential component of detoxifying enzymes and an energy producer. It is also involved in the formation of connective tissue, bones and nerve function.

It is also an important nutrient that is involved in many chemical processes in the body, including the processing of cholesterol, carbohydrates, and proteins.

The antioxidant properties of Manganese and its activity as a catalyst for the enzyme Manganese-dependent superoxide dismutase (MnSOD) are well known, which is why it is an important element in the processes of protection against oxidative damage. This enzyme, along with catalase, plays an important role in controlling this damage.

Manganese is a mineral found in various foods including nuts, legumes, seeds, tea, whole grains, and green leafy vegetables. It is considered an essential nutrient, because it is required for the normal functioning of the body.